2022 Las Vegas Challenger – Singles

J. J. Wolf was the defending champion but chose not to defend his title.

Tennys Sandgren won the title after defeating Stefan Kozlov 7–5, 6–3 in the final.

Seeds
• # 🇺🇸 Denis Kudla (first round)

• # 🇺🇸 Steve Johnson (semifinals)

• # 🇨🇦 Vasek Pospisil (first round)

• # 🇺🇸 Stefan Kozlov (final)

• # 🇦🇷 Juan Pablo Ficovich (quarterfinals, retired)

• # 🇺🇸 Ben Shelton (second round)

• # 🇦🇷 Facundo Mena (first round)

• # 🇺🇸 Aleksandar Kovacevic (second round)