2022 Lexington Challenger – Men's singles

Jason Kubler was the defending champion but chose not to defend his title.

Shang Juncheng won the title after defeating Emilio Gómez 6–4, 6–4 in the final.

Seeds
• # Roman Safiullin (quarterfinals)

• # 🇪🇨 Emilio Gómez (final)

• # 🇨🇿 Dalibor Svrčina (first round)

• # Gijs Brouwer (second round)

• # 🇰🇿 Mikhail Kukushkin (second round)

• # 🇦🇷 Genaro Alberto Olivieri (first round)

• # 🇺🇸 Aleksandar Kovacevic (semifinals)

• # 🇫🇷 Enzo Couacaud (semifinals)