2022 Lexington Challenger – Women's singles

Jennifer Brady was the defending champion but chose not to participate.

Katie Swan won the title, defeating Jodie Burrage in the final, 6–0, 3–6, 6–3.

Seeds
• # 🇯🇵 Moyuka Uchijima (second round)

• # 🇬🇧 Jodie Burrage (final)

• # 🇫🇷 Tessah Andrianjafitrimo (first round)

• # 🇦🇺 Priscilla Hon (first round)

• # 🇦🇺 Seone Mendez (first round)

• # 🇮🇱 Lina Glushko (first round, retired)

• # 🇦🇺 Lizette Cabrera (first round)

• # 🇬🇧 Katie Swan (champion)