2022 Libéma Open – Women's singles

Ekaterina Alexandrova defeated Aryna Sabalenka in the final, 7–5, 6–0 to win the women's singles title at the 2022 Rosmalen Grass Court Championships. It was her second WTA Tour singles title, and Alexandrova won the title despite being two points from defeat in the first round.

Alison Riske was the defending champion from when the event was last held in 2019, but she chose to compete in Nottingham instead.

Seeds
• # Aryna Sabalenka (final)

• # Belinda Bencic (quarterfinals)

• #🇰🇿 Elena Rybakina (second round)

• # Tamara Zidanšek (second round)

• # Liudmila Samsonova (first round)

• # Veronika Kudermetova (semifinals)

• # Ekaterina Alexandrova (champion)

• #🇧🇪 Elise Mertens (second round)

Seeds
• # Lesley Pattinama Kerkhove (first round)

• # Mariam Bolkvadze (first round)

• # 🇦🇺 Olivia Gadecki (qualified)

• # 🇺🇸 Alycia Parks (first round)

• # Anastasia Tikhonova (qualified)

• # 🇦🇺 Lizette Cabrera (first round)

• # 🇮🇹 Lucrezia Stefanini (first round)

• # Valentini Grammatikopoulou (qualifying competition)

• # 🇨🇿 Linda Fruhvirtová (qualifying competition)

• # 🇫🇮 Anastasia Kulikova (first round)

• # 🇫🇷 Jessika Ponchet (qualifying competition)

• # 🇺🇸 Jamie Loeb (qualified)

Qualifiers
• # 🇦🇺 Taylah Preston

• # 🇺🇸 Jamie Loeb

• # 🇦🇺 Olivia Gadecki

• # 🇦🇺 Storm Sanders

• # Anastasia Tikhonova

• # 🇺🇸 Caty McNally