2022 Lisboa Belém Open – Men's singles

Dmitry Popko was the defending champion but chose not to defend his title.

Marco Cecchinato won the title after defeating Luca Van Assche 6–3, 6–3 in the final.

Seeds
• # 🇦🇷 Pedro Cachin (first round)

• # 🇪🇸 Carlos Taberner (quarterfinals)

• # 🇮🇹 Francesco Passaro (second round)

• # 🇦🇹 Filip Misolic (semifinals, retired)

• # 🇮🇹 Marco Cecchinato (champion)

• # 🇮🇹 Franco Agamenone (second round)

• # 🇫🇷 Alexandre Müller (quarterfinals)

• # 🇫🇷 Manuel Guinard (first round)