2022 Los Cabos Open – Singles

Daniil Medvedev defeated the defending champion Cameron Norrie in the final, 7–5, 6–0 to win the singles tennis title. It was his 14th career ATP Tour title, his first of the season, and his first since the 2021 US Open eleven months earlier.

Seeds
The top four seeds receive a bye into the second round. • # Daniil Medvedev (champion)

• # 🇨🇦 Félix Auger-Aliassime (semifinals)

• # 🇬🇧 Cameron Norrie (final)

• # 🇷🇸 Miomir Kecmanović (semifinals)

• # 🇮🇹 Fabio Fognini (withdrew)

• # 🇺🇸 Brandon Nakashima (quarterfinals)

• # 🇦🇺 Thanasi Kokkinakis (second round)

• # 🇦🇷 Tomás Martín Etcheverry (first round)

• # 🇫🇷 Quentin Halys (first round)

Seeds
• # 🇯🇵 Kaichi Uchida (qualified)

• # 🇦🇺 Rinky Hijikata (qualified)

• # 🇦🇺 Max Purcell (qualified)

• # 🇫🇷 Maxime Janvier (first round)

• # 🇦🇷 Gonzalo Villanueva (qualifying competition, lucky loser)

• # 🇺🇸 Ulises Blanch (first round)

• # 🇨🇴 Nicolás Barrientos (qualifying competition, lucky loser)

• # 🇹🇳 Aziz Dougaz (qualifying competition)

Qualifiers
• # 🇯🇵 Kaichi Uchida

• # 🇦🇺 Rinky Hijikata

• # 🇦🇺 Max Purcell

• # 🇺🇸 Nick Chappell

Lucky losers
• # 🇦🇷 Gonzalo Villanueva

• # 🇨🇴 Nicolás Barrientos