2022 Matsuyama Challenger – Singles

This was the first edition of the tournament as an ATP Challenger Tour event.

Hong Seong-chan won the title after deafeating Wu Tung-lin 6–3, 6–2 in the final.

Seeds
• # 🇦🇺 Christopher O'Connell (withdrew)

• # 🇦🇺 Rinky Hijikata (first round)

• # 🇦🇺 John Millman (withdrew)

• # 🇯🇵 Kaichi Uchida (quarterfinals)

• # 🇫🇷 Benoît Paire (second round, retired)

• # 🇧🇦 Damir Džumhur (second round)

• # 🇦🇺 Li Tu (second round)

• # 🇯🇵 Rio Noguchi (first round)