2022 Mexico City Open – Singles

This was the first edition of the tournament.

Marc-Andrea Hüsler won the title after defeating Tomás Martín Etcheverry 6–4, 6–2 in the final.

Seeds
• # 🇦🇷 Facundo Bagnis (first round)

• # 🇦🇷 Tomás Martín Etcheverry (final)

• # 🇺🇸 Stefan Kozlov (first round, retired)

• # 🇸🇰 Andrej Martin (first round)

• # 🇦🇷 Juan Ignacio Londero (second round)

• # 🇺🇸 Ernesto Escobedo (first round)

• # Nicolás Jarry (semifinals)

• # 🇬🇧 Jay Clarke (second round)