2022 Monterrey Open – Singles

Defending champion Leylah Fernandez defeated Camila Osorio in the final, 6–7(5–7), 6–4, 7–6(7–3) to win the singles tennis title at the 2022 Monterrey Open. Fernandez saved five championship points en route to the title, all in the final set.

Initially, top seed Elina Svitolina from Ukraine, refused to play in protest of the Russian invasion of Ukraine, as she was due to face Russian player Anastasia Potapova in the first round. The match eventually went ahead after the Women's Tennis Association announced that Russian and Belarusian players would only be allowed to play under a neutral flag.

Seeds
• #🇺🇦 Elina Svitolina (quarterfinals)

• #🇨🇦 Leylah Fernandez (champion)

• #🇺🇸 Madison Keys (first round)

• #🇪🇸 Sara Sorribes Tormo (quarterfinals)

• #🇨🇴 Camila Osorio (final)

• #🇪🇸 Nuria Párrizas Díaz (semifinals)

• #🇺🇸 Sloane Stephens (withdrew)

• #🇺🇸 Ann Li (first round)

Seeds
• # 🇫🇷 Diane Parry (qualified)

• # 🇫🇷 Harmony Tan (qualified)

• # 🇧🇬 Viktoriya Tomova (qualified)

• # Kamilla Rakhimova (moved to main draw)

• # 🇭🇺 Dalma Gálfi (qualified)

• # 🇮🇹 Lucia Bronzetti (qualifying competition, lucky loser)

• # 🇩🇪 Jule Niemeier (qualified)

• # 🇺🇸 Hailey Baptiste (qualifying competition)

• # 🇸🇰 Viktória Kužmová (first round, retired)

• # 🇪🇸 Rebeka Masarova (first round)

• # 🇮🇹 Sara Errani (qualified)

• # 🇺🇸 Christina McHale (first round)

Qualifiers
• # 🇫🇷 Diane Parry

• # 🇫🇷 Harmony Tan

• # 🇧🇬 Viktoriya Tomova

• # 🇩🇪 Jule Niemeier

• # 🇭🇺 Dalma Gálfi

• # 🇮🇹 Sara Errani

Lucky losers
• # 🇮🇹 Lucia Bronzetti

• # 🇦🇺 Seone Mendez