2022 Montevideo Open – Singles

Diane Parry was the reigning champion, but chose not to participate.

Diana Shnaider won her first WTA 125K title, defeating Léolia Jeanjean in the final, 6–4, 6–4.

Seeds
• # 🇲🇪 Danka Kovinić (withdrew)

• # 🇭🇺 Panna Udvardy (withdrew)

• # Tamara Zidanšek (first round)

• # 🇮🇹 Sara Errani (first round)

• # 🇭🇺 Réka Luca Jani (first round)

• # 🇺🇦 Kateryna Baindl (semifinals)

• # 🇧🇷 Laura Pigossi (first round)

• # 🇰🇷 Jang Su-jeong (first round)

• # 🇦🇩 Victoria Jiménez Kasintseva (first round)

• # 🇫🇷 Léolia Jeanjean (final)

Seeds
• # 🇪🇸 Rosa Vicens Mas (moved to main draw)

• # Eva Vedder (qualified)

• # 🇨🇳 You Xiaodi (qualified)

• # 🇪🇸 Yvonne Cavallé Reimers (qualifying competition, lucky loser)

• # 🇺🇸 Whitney Osuigwe (qualifying competition)

• # 🇨🇴 Emiliana Arango (qualified)

• # Josefina Soldo (qualifying competition)

• # Juliana Rodriguez (qualifying competition)

Qualifiers
• # 🇭🇺 Tímea Babos

• # Eva Vedder

• # 🇨🇳 You Xiaodi

• # 🇨🇴 Emiliana Arango

Lucky loser
• # 🇪🇸 Yvonne Cavallé Reimers