2022 Morelos Open – Singles

Jurij Rodionov was the defending champion but chose not to defend his title.

Jay Clarke won the title after defeating Adrián Menéndez Maceiras 6–1, 4–6, 7–6(7–5) in the final.

Seeds
• # 🇺🇸 Ernesto Escobedo (quarterfinals)

• # Tim van Rijthoven (first round)

• # 🇬🇧 Jay Clarke (champion)

• # 🇦🇷 Juan Pablo Ficovich (first round)

• # 🇨🇦 Brayden Schnur (first round, retired)

• # 🇨🇴 Nicolás Mejía (second round)

• # 🇯🇵 Yūichi Sugita (first round, retired)

• # 🇦🇺 Rinky Hijikata (semifinals)