2022 Murcia Open – Singles

Tallon Griekspoor was the defending champion but chose not to defend his title.

Tseng Chun-hsin won the title after defeating Norbert Gombos 6–4, 6–1 in the final.

Seeds
• # 🇸🇰 Norbert Gombos (final)

• # 🇦🇷 Juan Manuel Cerúndolo (first round, retired)

• # 🇦🇹 Dennis Novak (semifinals)

• # Tseng Chun-hsin (champion)

• # 🇪🇸 Mario Vilella Martínez (withdrew)

• # 🇩🇪 Maximilian Marterer (first round)

• # 🇦🇷 Marco Trungelliti (quarterfinals)

• # 🇮🇹 Andrea Pellegrino (first round)