2022 Mutua Madrid Open – Women's doubles

Gabriela Dabrowski and Giuliana Olmos defeated Desirae Krawczyk and Demi Schuurs in the final, 7–6(7–1), 5–7, [10–7] to win the women's doubles tennis title at the 2022 Madrid Open. This was Dabrowski's third consecutive final at the tournament, having lost the previous two editions in 2021 and 2019.

Barbora Krejčíková and Kateřina Siniaková were the defending champions, but Krejčíková could not defend her title due to injury. Siniaková played alongside Leylah Fernandez, but lost in the second round to Ulrikke Eikeri and Tereza Mihalíková.

Seeds
The two top seeds received a bye into the second round. • # 🇦🇺 Storm Sanders / 🇨🇳 Zhang Shuai (semifinals)

• # 🇨🇦 Gabriela Dabrowski / 🇲🇽 Giuliana Olmos (champions)

• # 🇺🇸 Desirae Krawczyk / Demi Schuurs (final)

• # Alexa Guarachi /  Andreja Klepač (first round)

• # 🇺🇸 Coco Gauff / 🇺🇸 Jessica Pegula (quarterfinals)

• # 🇰🇿 Anna Danilina / 🇧🇷 Beatriz Haddad Maia (first round)

• # 🇨🇳 Xu Yifan / 🇨🇳 Yang Zhaoxuan (first round)

• # 🇯🇵 Shuko Aoyama / Chan Hao-ching (second round)

Seeded teams
The following are the seeded teams, based on WTA rankings as of April 25, 2022.

Wildcards

 * 🇪🇸 Cristina Bucșa / 🇪🇸 Nuria Párrizas Díaz

Protected ranking
• 🇩🇪 Julia Lohoff / 🇨🇿 Renata Voráčová

• 🇨🇳 Xinyun Han / Alexandra Panova

Withdrawals

 * Before the tournament
 * 🇳🇴 Ulrikke Eikeri / 🇺🇸 Catherine Harrison → replaced by 🇳🇴 Ulrikke Eikeri / 🇸🇰 Tereza Mihalíková
 * 🇨🇿 Lucie Hradecká / 🇮🇳 Sania Mirza → replaced by 🇺🇸 Kaitlyn Christian / Oksana Kalashnikova
 * 🇺🇦 Nadiia Kichenok / 🇷🇴 Raluca Olaru → replaced by 🇺🇦 Nadiia Kichenok / Ekaterine Gorgodze
 * Veronika Kudermetova / 🇧🇪 Elise Mertens → replaced by 🇰🇿 Elena Rybakina / Liudmila Samsonova
 * 🇨🇿 Tereza Martincová / 🇨🇿 Markéta Vondroušová → replaced by 🇩🇪 Julia Lohoff / 🇨🇿 Renata Voráčová
 * Alexandra Panova / 🇷🇴 Monica Niculescu → replaced by Alexandra Panova / 🇨🇳 Han Xinyun