2022 Mutua Madrid Open – Women's singles

Ons Jabeur defeated Jessica Pegula in the final, 7–5, 0–6, 6–2 to win the women's singles tennis title at the 2022 Madrid Open. It was her first WTA 1000 title, and she became the first Arab and African woman to win a WTA 1000 title.

Pegula reached the final after being a match point down against Camila Giorgi in the first round.

Aryna Sabalenka was the defending champion, but lost in the first round to Amanda Anisimova.

Simona Halep's loss in the quarterfinals guaranteed a maiden WTA 1000 finalist from the bottom half of the draw as well as a first-time champion at the Madrid Open.

This marked the last professional appearance for Olympic champion Monica Puig; she lost to Danielle Collins in the first round.

Seeds
• 🇵🇱 Iga Świątek (withdrew)

• 🇪🇸 Paula Badosa (second round)

• Aryna Sabalenka (first round)

•  Maria Sakkari (second round)

• 🇨🇿 Karolína Plíšková (first round)

• 🇺🇸 Danielle Collins (second round)

• 🇪🇸 Garbiñe Muguruza (second round)

• 🇹🇳 Ons Jabeur (champion)

• 🇬🇧 Emma Raducanu (third round)

•  Jeļena Ostapenko (first round)

•  Belinda Bencic (third round)

• 🇺🇸 Jessica Pegula (final)

•  Anastasia Pavlyuchenkova (first round)

• 🇺🇸 Coco Gauff (third round)

•  Victoria Azarenka (third round)

• 🇰🇿 Elena Rybakina (third round)

• 🇨🇦 Leylah Fernandez (second round)

Seeded players
The following are the seeded players based on the entry list as of 25 April 2022. Rankings and points before are as of 25 April 2022. † The player did not qualify for the tournament in 2021. Accordingly, points from her 16th best tournament will be deducted instead.

Withdrawn players
The following players would have been seeded, but withdrew before the tournament began. † The player is not required to count zero points from this mandatory tournament due to a long-term injury exemption.

Wildcards
• 🇨🇿 Linda Fruhvirtová

• 🇺🇦 Marta Kostyuk

• 🇯🇵 Naomi Osaka

• Monica Puig

• 🇨🇳 Zheng Qinwen

Source:

Protected ranking

 * 🇨🇿 Karolína Muchová

Qualifiers
• Ekaterina Alexandrova

• 🇷🇴 Irina-Camelia Begu

• 🇭🇺 Anna Bondár

• 🇨🇿 Marie Bouzková

• 🇫🇷 Océane Dodin

•  Varvara Gracheva

• 🇪🇪 Kaia Kanepi

•  Petra Martić

• 🇩🇪 Andrea Petkovic

•  Anastasia Potapova

• 🇸🇰 Anna Karolína Schmiedlová

• 🇺🇦 Dayana Yastremska

Lucky losers
• 🇧🇷 Beatriz Haddad Maia

• 🇧🇪 Greet Minnen

Withdrawals
• 🇺🇸 Sofia Kenin → replaced by 🇰🇿 Yulia Putintseva

• 🇩🇪 Angelique Kerber → replaced by 🇨🇿 Kateřina Siniaková

• 🇪🇪 Anett Kontaveit → replaced by Ana Konjuh

• 🇨🇿 Barbora Krejčíková → replaced by 🇺🇸 Alison Riske

• 🇧🇪 Elise Mertens → replaced by 🇧🇷 Beatriz Haddad Maia

• 🇨🇴 Camila Osorio → replaced by 🇺🇸 Shelby Rogers

• 🇺🇦 Elina Svitolina → replaced by 🇺🇦 Anhelina Kalinina

• 🇵🇱 Iga Świątek → replaced by 🇧🇪 Greet Minnen

• 🇨🇿 Markéta Vondroušová → replaced by 🇪🇸 Nuria Párrizas Díaz

Seeds
• # Ekaterina Alexandrova (qualified)

• #  Aliaksandra Sasnovich (first round)

• # 🇺🇸 Madison Brengle (first round)

• # 🇪🇪 Kaia Kanepi (qualified)

• # 🇵🇱 Magda Linette (qualifying competition)

• # Petra Martić (qualified)

• # 🇪🇬 Mayar Sherif (first round)

• # 🇷🇴 Irina-Camelia Begu (qualified)

• # 🇩🇪 Andrea Petkovic (qualified)

• # 🇧🇷 Beatriz Haddad Maia (qualifying competition, lucky loser)

• # 🇭🇺 Anna Bondár (qualified)

• #  Varvara Gracheva (qualified)

• # 🇨🇿 Marie Bouzková (qualified)

• #  Anastasia Potapova (qualified)

• # 🇧🇪 Greet Minnen (qualifying competition, lucky loser)

• # 🇮🇹 Lucia Bronzetti (qualifying competition)

• # 🇮🇹 Martina Trevisan (qualifying competition)

• # Kaja Juvan (qualifying competition)

• # 🇭🇺 Panna Udvardy (first round)

• # 🇫🇷 Clara Burel (qualifying competition)

• # 🇸🇰 Kristína Kučová (first round)

• # 🇵🇱 Magdalena Fręch (first round)

• # 🇸🇰 Anna Karolína Schmiedlová (qualified)

• # 🇺🇸 Lauren Davis (first round)

Qualifiers
• # Ekaterina Alexandrova

• # 🇨🇿 Marie Bouzková

• # 🇺🇦 Dayana Yastremska

• # 🇪🇪 Kaia Kanepi

• # 🇸🇰 Anna Karolína Schmiedlová

• # Petra Martić

• # Anastasia Potapova

• # 🇷🇴 Irina-Camelia Begu

• # 🇩🇪 Andrea Petkovic

• # 🇫🇷 Océane Dodin

• # 🇭🇺 Anna Bondár

• # Varvara Gracheva

Lucky losers
• # 🇧🇷 Beatriz Haddad Maia

• # 🇧🇪 Greet Minnen