2022 National Bank Open – Women's singles

Simona Halep defeated Beatriz Haddad Maia in the final, 6–3, 2–6, 6–3 to win the women's singles tennis title at the 2022 Canadian Open. Halep's third Canadian Open title marked the first time in her career she won an event on three occasions and also earned her a ninth WTA 1000 title. Haddad Maia was the first Brazilian to reach beyond the quarterfinals and contest the final at a WTA 1000 tournament.

Camila Giorgi was the defending champion, but lost in the third round to Jessica Pegula in a rematch of last year's semifinal.

This marked the final Canadian Open appearance for three-time champion and former world No. 1 Serena Williams, who lost in the second round to Belinda Bencic.

Seeds
The top eight seeds received a bye into the second round. • 🇵🇱 Iga Świątek (third round)

• 🇪🇪 Anett Kontaveit (second round)

• Maria Sakkari (third round)

• 🇪🇸 Paula Badosa (second round, retired)

• 🇹🇳 Ons Jabeur (second round, retired)

•  Aryna Sabalenka (third round)

• 🇺🇸 Jessica Pegula (semifinals)

• 🇪🇸 Garbiñe Muguruza (third round)

• 🇬🇧 Emma Raducanu (first round)

• 🇺🇸 Coco Gauff (quarterfinals)

•  Daria Kasatkina (first round)

•  Belinda Bencic (quarterfinals)

• 🇨🇦 Leylah Fernandez (second round)

• 🇨🇿 Karolína Plíšková (semifinals)

• 🇷🇴 Simona Halep (champion)

•  Jeļena Ostapenko (second round)

Seeded players
The following are the seeded players. Seedings are based on WTA rankings as of August 1, 2022. Rank and points before are as of August 8, 2022.

The event is not mandatory on the women's side and points from the 2021 tournament are included in the table below only if they counted towards the player's ranking as of August 8, 2022. For other players, the points defending column shows the lower of (a) points from her second-highest non-mandatory WTA 1000 tournament (which are required to be counted in her ranking) or (b) her 16th best result.

Points defending will be replaced at the end of the tournament by (a) the player's points from the 2022 tournament, (b) her 17th best result, or (c) points from her second-highest non-mandatory WTA 1000 event.

† Points from the player's 16th best result (for points defending) or 17th best result (for points won), in each case as of August 8, 2022. ‡ Points from the player's second-best non-mandatory WTA 1000 event, which are required to be counted in her ranking. § The player is defending points from an ITF tournament (2021 Landisville or 2019 Vancouver).

Withdrawn players
The following players would have been seeded, but withdrew before the tournament began.

Wild cards
• 🇨🇦 Rebecca Marino

• 🇨🇦 Katherine Sebov

• 🇺🇸 Venus Williams

• 🇨🇦 Carol Zhao

Protected ranking
• 🇺🇸 Sofia Kenin

• 🇺🇸 Serena Williams

Withdrawals
• Ekaterina Alexandrova → replaced by 🇨🇳 Zheng Qinwen

•  Victoria Azarenka → replaced by 🇪🇸 Nuria Párrizas Díaz

• 🇷🇴 Sorana Cîrstea → replaced by 🇨🇦 Bianca Andreescu

• 🇺🇸 Danielle Collins → replaced by  Donna Vekić

•  Aliaksandra Sasnovich → replaced by 🇫🇷 Caroline Garcia

• 🇧🇪 Alison Van Uytvanck → replaced by 🇺🇸 Sloane Stephens

Retirements
• 🇪🇸 Paula Badosa (muscle cramping)

• 🇹🇳 Ons Jabeur (abdominal pain)

• 🇯🇵 Naomi Osaka (low back injury)

Seeds
• # 🇨🇿 Marie Bouzková (qualified)

• # 🇪🇸 Nuria Párrizas Díaz (qualifying competition, lucky loser)

• # Liudmila Samsonova (withdrew, competing in Washington)

• # 🇺🇸 Madison Brengle (qualified)

• # 🇨🇴 Camila Osorio (withdrew)

• # 🇩🇪 Andrea Petkovic (first round)

• # 🇦🇺 Ajla Tomljanović (qualified)

• # 🇨🇿 Tereza Martincová (qualified)

• # 🇨🇳 Wang Xinyu (first round, retired)

• # 🇺🇸 Claire Liu (qualified)

• # 🇬🇧 Harriet Dart (qualifying competition)

• # Donna Vekić (qualifying competition, lucky loser)

• # 🇦🇺 Daria Saville (withdrew, competing in Washington)

• # 🇸🇪 Rebecca Peterson (first round)

• # 🇩🇪 Tatjana Maria (qualifying competition)

• # 🇺🇸 Lauren Davis (qualifying competition)

Qualifiers
• # 🇨🇿 Marie Bouzková

• # 🇪🇸 Cristina Bucșa

• # 🇦🇺 Storm Sanders

• # 🇺🇸 Madison Brengle

• # 🇺🇸 Claire Liu

• # 🇺🇸 Asia Muhammad

• # 🇦🇺 Ajla Tomljanović

• # 🇨🇿 Tereza Martincová

Lucky losers
• # 🇪🇸 Nuria Párrizas Díaz

• # Donna Vekić