2022 Odlum Brown Vancouver Open – Women's singles

Heather Watson was the defending champion from when the tournament was last held in 2019 as part of the ITF Women's World Tennis Tour, but lost in the second round to Chloé Paquet.

Valentini Grammatikopoulou won the title, defeating Lucia Bronzetti in the final, 6–2, 6–4.

Seeds
• # 🇺🇸 Madison Brengle (quarterfinals)

• # 🇮🇹 Lucia Bronzetti (final)

• # 🇺🇸 Claire Liu (first round)

• # 🇨🇳 Wang Xinyu (second round)

• # 🇸🇪 Rebecca Peterson (semifinals)

• # 🇨🇦 Rebecca Marino (first round)

• # 🇯🇵 Misaki Doi (first round)

• # 🇮🇹 Elisabetta Cocciaretto (first round)

Seeds
• # 🇦🇺 Priscilla Hon (qualified)

• # 🇺🇸 Asia Muhammad (qualifying competition)

• # 🇫🇷 Elsa Jacquemot (first round)

• # 🇯🇵 Nao Hibino (first round, retired)

• # 🇬🇧 Yuriko Miyazaki (qualified)

• # 🇪🇸 Marina Bassols Ribera (first round)

• # 🇯🇵 Kurumi Nara (qualifying competition, lucky loser)

• # Valentini Grammatikopoulou (qualified)

Qualifiers
• # 🇦🇺 Priscilla Hon

• # Valentini Grammatikopoulou

• # 🇬🇧 Yuriko Miyazaki

• # 🇺🇸 Catherine Harrison

Lucky loser
• # 🇯🇵 Kurumi Nara