2022 Open Bogotá – Singles

Gerald Melzer was the defending champion but lost in the final to Juan Pablo Ficovich.

Ficovich won the title after defeating Melzer 6–1, 6–2 in the final.

Seeds
• # 🇦🇷 Facundo Mena (second round)

• # 🇦🇷 Juan Pablo Ficovich (champion)

• # 🇧🇷 Felipe Meligeni Alves (quarterfinals)

• # 🇦🇷 Francisco Comesaña (withdrew)

• # 🇦🇹 Gerald Melzer (final)

• # Gonzalo Lama (first round)

• # 🇷🇸 Miljan Zekić (semifinals)

• # 🇦🇷 Gonzalo Villanueva (second round)

• # 🇺🇸 Aleksandar Kovacevic (first round)