2022 Open Castilla y León – Singles

Benjamin Bonzi was the defending champion but chose not to defend his title.

Hugo Grenier won the title after defeating Constant Lestienne 7–5, 6–3 in the final.

Seeds
• # Nuno Borges (quarterfinals)

• # 🇫🇷 Constant Lestienne (final)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇫🇷 Hugo Grenier (champion)

• # 🇫🇷 Ugo Humbert (semifinals)

• # 🇹🇷 Altuğ Çelikbilek (first round)

• # 🇰🇿 Dmitry Popko (first round)

• # 🇫🇷 Grégoire Barrère (quarterfinals)