2022 Open Città della Disfida

The 2022 Open Città della Disfida was a professional tennis tournament played on clay courts. It was the 22nd edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Barletta, Italy between 11 and 17 April 2022.

Seeds

 * 1 Rankings are as of 4 April 2022.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇮🇹 Luca Nardi
 * 🇺🇦 Oleksandr Ovcharenko
 * 🇮🇹 Francesco Passaro

The following players received entry into the singles main draw as alternates:
 * Evgeny Karlovskiy
 * Jelle Sels
 * Alexander Shevchenko

The following players received entry from the qualifying draw:
 * 🇮🇹 Matteo Arnaldi
 * 🇮🇹 Luciano Darderi
 * 🇫🇷 Titouan Droguet
 * 🇮🇹 Francesco Forti
 * 🇩🇪 Lucas Gerch
 * 🇷🇸 Miljan Zekić

Singles

 * Nuno Borges def. 🇷🇸 Miljan Zekić 6–3, 7–5.

Doubles

 * Evgeny Karlovskiy / Evgenii Tiurnev def. 🇯🇵 Ben McLachlan / 🇵🇱 Szymon Walków 6–3, 6–4.