2022 Open Città della Disfida – Singles

Giulio Zeppieri was the defending champion but lost in the first round to Matteo Arnaldi.

Nuno Borges won the title after defeating Miljan Zekić 6–3, 7–5 in the final.

Seeds
• # 🇫🇷 Gilles Simon (first round)

• # Nuno Borges (champion)

• # 🇨🇿 Zdeněk Kolář (semifinals)

• # 🇦🇹 Jurij Rodionov (first round)

• # 🇮🇹 Franco Agamenone (first round)

• # 🇫🇷 Enzo Couacaud (second round)

• # 🇫🇷 Constant Lestienne (first round)

• # 🇵🇱 Kacper Żuk (first round)