2022 Open Ciudad de Valencia – Singles

Arantxa Rus was the defending champion but lost in the second round to Leyre Romero Gormaz.

Marina Bassols Ribera won the title, defeating Ylena In-Albon in the final, 6–4, 6–0.

Seeds
• # 🇩🇪 Tamara Korpatsch (semifinals)

• # 🇪🇸 Cristina Bucșa (first round)

• # 🇫🇷 Océane Dodin (quarterfinals, retired)

• # 🇫🇷 Kristina Mladenovic (first round, retired)

• # 🇵🇱 Magdalena Fręch (second round, retired)

• # Arantxa Rus (second round)

• # 🇺🇸 Alycia Parks (semifinals)

• # 🇪🇸 Rebeka Masarova (second round)