2022 Open Delle Puglie – Singles

This was the first edition of the tournament.

Julia Grabher won the title, defeating Nuria Brancaccio 6–4, 6–2 in the final.

Seeds
• # 🇭🇺 Panna Udvardy (quarterfinals)

• # 🇲🇪 Danka Kovinić (second round)

• # 🇩🇪 Tatjana Maria (quarterfinals)

• # 🇧🇪 Maryna Zanevska (first round, retired)

• # 🇮🇹 Elisabetta Cocciaretto (quarterfinals)

• # 🇧🇷 Laura Pigossi (second round)

• # 🇫🇷 Harmony Tan (first round)

• # 🇷🇸 Olga Danilović (first round)

Seeds
• # 🇨🇾 Raluca Șerban (moved to the main draw)

• # Dalila Jakupović (moved to the main draw)

• # 🇦🇷 Paula Ormaechea (qualified)

• # Ekaterina Makarova (qualifying competition)

• # Eva Vedder (qualified)

• # 🇷🇴 Andreea Roșca (qualified)

• # 🇮🇹 Nuria Brancaccio (qualified)

• # 🇮🇹 Diletta Cherubini (qualifying competition)

Qualifiers
• # 🇷🇴 Andreea Roșca

• # 🇮🇹 Nuria Brancaccio

• # 🇦🇷 Paula Ormaechea

• # Eva Vedder

Lucky losers
• # 🇻🇪 Andrea Gámiz

• # 🇷🇴 Ioana Loredana Roșca