2022 Open ITF Arcadis Brezo Osuna – Singles

Robin Anderson was the defending champion but chose to participate at the 2022 Ilkley Trophy instead.

Marina Bassols Ribera won the title, defeating Alex Eala in the final, 6–4, 7–5.

Seeds
All seeds receive a bye into the second round. • # 🇨🇳 Zhu Lin (second round, withdrew)

• # Anastasia Tikhonova (third round)

• # 🇦🇺 Jaimee Fourlis (quarterfinals)

• # Richèl Hogenkamp (second round)

• # 🇫🇷 Carole Monnet (quarterfinals)

• # 🇭🇺 Tímea Babos (quarterfinals)

• # 🇪🇸 Yvonne Cavallé Reimers (third round)

• # Valeria Savinykh (second round)

• # 🇩🇪 Stephanie Wagner (third round)

• # 🇨🇳 You Xiaodi (third round)

• # Daniela Seguel (second round)

• # 🇪🇸 Jéssica Bouzas Maneiro (third round)

• # 🇨🇳 Lu Jiajing (second round)

• # 🇪🇸 Marina Bassols Ribera (champion)

• # Liang En-shuo (quarterfinals)

• # 🇨🇦 Katherine Sebov (semifinals)