2022 Open de Oeiras III – Singles

Gastão Elias was the three-time defending champion but chose not to defend his title.

Kaichi Uchida won the title after defeating Kimmer Coppejans 6–2, 6–4 in the final.

Seeds
• # 🇪🇸 Roberto Carballés Baena (first round)

• # 🇦🇷 Facundo Bagnis (semifinals)

• # Nicolás Jarry (semifinals)

• # 🇧🇷 Daniel Dutra da Silva (first round)

• # Evgeny Karlovskiy (first round)

• # 🇯🇵 Kaichi Uchida (champion)

• # Johan Nikles (second round)

• # 🇫🇷 Laurent Lokoli (first round)