2022 Open de Rennes – Singles

Benjamin Bonzi was the defending champion but chose not to defend his title.

Ugo Humbert won the title after defeating Dominic Thiem 6–3, 6–0 in the final.

Seeds
• # 🇫🇷 Hugo Gaston (semifinals)

• # 🇩🇪 Peter Gojowczyk (semifinals)

• # 🇫🇷 Hugo Grenier (second round)

• # 🇫🇷 Ugo Humbert (champion)

• # 🇬🇧 Ryan Peniston (second round)

• # 🇫🇷 Grégoire Barrère (quarterfinals)

• # 🇫🇷 Benoît Paire (quarterfinals)

• # Gijs Brouwer (quarterfinals)