2022 Ostrava Open – Singles

Barbora Krejčíková defeated Iga Świątek in the final, 5–7, 7–6(7–4), 6–3 to win the singles tennis title at the 2022 Ostrava Open. It was Krejčíková's second WTA Tour title in back-to-back weeks, and she ended Świątek's streak of ten consecutive victories in WTA Tour finals. This marked only Świątek's second career loss in a WTA Tour-level final, out of twelve played (the other being at the 2019 Ladies Open Lugano).

Anett Kontaveit was the defending champion, but retired in the second round against Tereza Martincová.

Seeds
The top four seeds received a bye into the second round. • # 🇵🇱 Iga Świątek (final)

• # 🇪🇸 Paula Badosa (second round)

• # 🇪🇪 Anett Kontaveit (second round, retired)

• # Maria Sakkari (second round)

• # Daria Kasatkina (second round)

• # Belinda Bencic (second round, withdrew)

• # 🇧🇷 Beatriz Haddad Maia (first round)

• # Jeļena Ostapenko (first round)

Seeds
• # 🇦🇺 Ajla Tomljanović (qualified)

• # 🇺🇸 Bernarda Pera (qualified)

• # 🇺🇦 Marta Kostyuk (withdrew)

• # 🇨🇳 Wang Xiyu (first round)

• # 🇭🇺 Dalma Gálfi (qualifying competition)

• # 🇩🇪 Tamara Korpatsch (qualifying competition)

• # 🇫🇷 Océane Dodin (first round)

• # 🇨🇿 Linda Nosková (first round)

• # 🇺🇦 Daria Snigur (first round)

• # 🇸🇰 Anna Karolína Schmiedlová (qualifying competition)

• # Anna Blinkova (qualified)

• # Oksana Selekhmeteva (first round)

Qualifiers
• # 🇦🇺 Ajla Tomljanović

• # 🇺🇸 Bernarda Pera

• # 🇺🇸 Alycia Parks

• # 🇺🇸 Caty McNally

• # 🇨🇦 Eugenie Bouchard

• # Anna Blinkova