2022 Penrith Panthers season

The 2022 Penrith Panthers season is the 56th season in the club's history. Coached by Ivan Cleary and co-captained by Nathan Cleary and Isaah Yeo, the Panthers are competing in the National Rugby League's 2022 Telstra Premiership.

Player transfers
A † denotes that the transfer occurred during the 2022 season.

Regular season

 * Round 10 attendance refers to the total attendance on day 2 of magic round

Other teams
In addition to competing in the National Rugby League, the Panthers are also fielding semi-professional teams in the 2022 Jersey Flegg Cup (for players aged under 21) and the New South Wales Rugby League's The Knock-On Effect NSW Cup (NSW Cup). The 2022 season brought success to the Penrith Panthers seeing them become premiers in SG Ball, Jersey Flegg and NSW Cup.