2022 Porto Open – Singles

Altuğ Çelikbilek was the defending champion and successfully defended his title after Christopher O'Connell retired at 7–6(7–5), 3–1 down in the final.

Seeds
• # 🇦🇺 James Duckworth (semifinals)

• # 🇯🇵 Yoshihito Nishioka (semifinals)

• # 🇦🇺 Christopher O'Connell (final, retired)

• # Nuno Borges (first round)

• # 🇫🇷 Hugo Grenier (quarterfinals, retired)

• # Egor Gerasimov (quarterfinals)

• # 🇫🇷 Constant Lestienne (first round, retired)

• # 🇪🇨 Emilio Gómez (withdrew)