2022 Prague Open – Doubles

Anastasia Potapova and Yana Sizikova defeated Angelina Gabueva and Anastasia Zakharova in the final, 6–3, 6–4 to win the doubles tennis title at the 2022 Prague Open.

Marie Bouzková and Lucie Hradecká were the defending champions, but Bouzková did not participate. Hradecká partnered Andrea Sestini Hlaváčková in the latter's final professional tournament, but lost in the quarterfinals to Miyu Kato and Samantha Murray Sharan.

Seeds
• # 🇧🇪 Kirsten Flipkens / 🇧🇪 Alison Van Uytvanck (withdrew)

• # 🇨🇳 Han Xinyun / Alexandra Panova (first round)

• # 🇯🇵 Miyu Kato / 🇬🇧 Samantha Murray Sharan (semifinals, withdrew)

• # Anastasia Potapova /  Yana Sizikova (champions)