2022 Prague Open – Singles

Marie Bouzková defeated Anastasia Potapova in the final, 6–0, 6–3 to win the singles tennis title at the 2022 Prague Open. It was her maiden WTA Tour title.

Barbora Krejčíková was the defending champion, but lost in the second round to Nao Hibino.

Seeds
• # 🇪🇪 Anett Kontaveit (quarterfinals)

• # 🇨🇿 Barbora Krejčíková (second round)

• # 🇧🇪 Elise Mertens (first round)

• # 🇷🇴 Sorana Cîrstea (first round)

• # 🇫🇷 Alizé Cornet (second round)

• # 🇧🇪 Alison Van Uytvanck (first round, retired)

• # Anastasia Potapova (final)

• # 🇨🇿 Marie Bouzková (champion)

Seeds
• # 🇨🇳 Yuan Yue (first round)

• # 🇨🇳 Wang Qiang (qualified)

• # Anastasia Zakharova (qualified)

• # 🇦🇺 Astra Sharma (first round)

• # Oksana Selekhmeteva (qualified)

• # 🇸🇰 Viktória Kužmová (first round)

• # 🇦🇺 Lizette Cabrera (first round)

• # 🇬🇧 Yuriko Miyazaki (first round)

• # 🇦🇹 Sinja Kraus (qualifying competition, lucky loser)

• # 🇮🇱 Lina Glushko (qualifying competition)

• # Natalia Vikhlyantseva (qualifying competition, lucky loser)

• # 🇸🇰 Rebecca Šramková (first round)

Qualifiers
• # Dalila Jakupović

• # 🇨🇳 Wang Qiang

• # Anastasia Zakharova

• # 🇨🇿 Dominika Šalková

• # Oksana Selekhmeteva

• # 🇨🇿 Barbora Palicová

Lucky losers
• # 🇦🇹 Sinja Kraus

• # Natalia Vikhlyantseva

• # 🇯🇵 Nao Hibino