2022 Queen's Club Championships – Singles

Defending champion Matteo Berrettini defeated Filip Krajinović in the final, 7–5, 6–4 to win the singles tennis title at the 2022 Queen's Club Championships. By winning his fourth title on grass and seventh career ATP Tour singles title overall, Berrettini became the first player in the Open Era to claim the title in their first two appearances at the tournament. Krajinović had never earned a tour-level win on grass before the tournament and was seeking his first career title in his fifth final.

Seeds
• 🇳🇴 Casper Ruud (first round)

• 🇮🇹 Matteo Berrettini (champion)

• 🇬🇧 Cameron Norrie (first round)

• 🇺🇸 Taylor Fritz (first round)

• 🇦🇷 Diego Schwartzman (first round)

• 🇨🇦 Denis Shapovalov (first round)

• Marin Čilić (semifinals)

• 🇺🇸 Reilly Opelka (first round)

Seeds
• 🇫🇮 Emil Ruusuvuori (qualified)

• 🇺🇸 Brandon Nakashima (withdrew)

• 🇦🇺 James Duckworth (first round)

• 🇺🇸 Denis Kudla (qualifying competition, lucky loser)

• 🇵🇱 Kamil Majchrzak (first round)

• Alejandro Tabilo (first round)

• 🇦🇺 Thanasi Kokkinakis (withdrew)

• 🇺🇸 Steve Johnson (qualifying competition)

Qualifiers
• 🇫🇮 Emil Ruusuvuori

• 🇺🇸 Sam Querrey

• 🇬🇧 Paul Jubb

• 🇫🇷 Quentin Halys

Lucky loser
• 🇺🇸 Denis Kudla