2022 República Dominicana Open – Singles

Juan Pablo Varillas was the defending champion but lost in the first round to Thiago Agustín Tirante.

Pedro Cachin won the title after defeating Marco Trungelliti 6–4, 2–6, 6–3 in the final.

Seeds
• # 🇪🇸 Roberto Carballés Baena (quarterfinals)

• # 🇦🇷 Pedro Cachin (champion)

• # 🇦🇷 Tomás Martín Etcheverry (semifinals)

• # 🇨🇴 Daniel Elahi Galán (semifinals)

• # 🇵🇪 Juan Pablo Varillas (first round)

• # 🇦🇷 Camilo Ugo Carabelli (second round)

• # 🇦🇷 Federico Delbonis (second round)

• # 🇦🇷 Facundo Mena (quarterfinals)