2022 São Léo Open – Doubles

This was the third edition of the tournament as an ATP Challenger Tour event and the first edition since 2012.

Guido Andreozzi and Guillermo Durán won the title leading 5–1 in the final after Felipe Meligeni Alves and João Lucas Reis da Silva retired.

Seeds
• # 🇦🇷 Guido Andreozzi / 🇦🇷 Guillermo Durán (champions)

• # 🇧🇴 Boris Arias / 🇧🇴 Federico Zeballos (quarterfinals)

• # 🇧🇷 Daniel Dutra da Silva / 🇻🇪 Luis David Martínez (first round)

• # 🇰🇿 Grigoriy Lomakin / Damien Wenger (first round)