2022 São Léo Open – Singles

This was the third edition of the tournament as an ATP Challenger Tour event and the first edition since 2012.

Juan Pablo Varillas won the title after defeating Facundo Bagnis 7–6(7–5), 4–6, 6–4 in the final.

Seeds
• # 🇦🇷 Facundo Bagnis (final)

• # 🇵🇪 Juan Pablo Varillas (champion)

• # 🇮🇹 Franco Agamenone (first round, retired)

• # 🇧🇷 Felipe Meligeni Alves (semifinals)

• # 🇦🇷 Renzo Olivo (first round)

• # 🇦🇷 Facundo Díaz Acosta (second round)

• # 🇧🇷 Matheus Pucinelli de Almeida (first round)

• # Gastão Elias (first round)