2022 Saint-Tropez Open – Singles

Benjamin Bonzi was the defending champion but chose not to defend his title.

Mattia Bellucci won the title after defeating Matteo Arnaldi 6–3, 6–3 in the final.

Seeds
• # 🇫🇷 Hugo Gaston (withdrew)

• # 🇫🇷 Hugo Grenier (second round)

• # 🇫🇷 Ugo Humbert (semifinals)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇫🇷 Grégoire Barrère (quarterfinals)

• # 🇺🇸 Jack Sock (first round, retired)

• # 🇦🇹 Jurij Rodionov (semifinals)

• # 🇫🇷 Geoffrey Blancaneaux (first round)

• # Alexander Shevchenko (first round)