2022 San Benedetto Tennis Cup – Singles

Renzo Olivo was the defending champion but lost in the semifinals to Andrea Vavassori.

Raúl Brancaccio won the title after defeating Vavassori 6–1, 6–1 in the final.

Seeds
• # 🇮🇹 Andrea Pellegrino (quarterfinals)

• # 🇮🇹 Luciano Darderi (semifinals)

• # 🇮🇹 Francesco Passaro (second round)

• # 🇦🇷 Nicolás Kicker (first round, retired)

• # 🇦🇷 Andrea Collarini (second round, retired)

• # 🇮🇹 Alessandro Giannessi (first round)

• # 🇦🇷 Renzo Olivo (semifinals)

• # 🇧🇷 Matheus Pucinelli de Almeida (second round)