2022 San Diego Open

The 2022 San Diego Open was a combined men's and women's tennis tournament played on outdoor hard courts. It was the 2nd edition of the event for the men and the 1st edition of the Southern California Open for the women since 2015. The event is part of the ATP Tour 250 series of the 2022 ATP Tour and a WTA 500 event on the 2022 WTA Tour. It was held at the Barnes Tennis Center in San Diego, United States, from September 19 through September 25, 2022 for the men, and from October 10 through October 16, 2022 for the women.

The event was primarily organized being held on a second consecutive year in the alternative sporting calendar due to the cancellation of tournaments in China during the 2022 season because of the ongoing COVID-19 pandemic, as well as the WTA's suspension of tournaments in China following former WTA player Peng Shuai's allegation of sexual assault against a Chinese government official.

Men's singles

 * 🇺🇸 Brandon Nakashima def. 🇺🇸 Marcos Giron, 6–4, 6–4

Women's singles

 * 🇵🇱 Iga Świątek def. Donna Vekić, 6–3, 3–6, 6–0

This is Świątek's eighth title of the year and eleventh of her career.

Men's doubles

 * 🇺🇸 Nathaniel Lammons / 🇺🇸 Jackson Withrow def. 🇦🇺 Jason Kubler / 🇦🇺 Luke Saville, 7–6(7–5), 6–2

Women's doubles

 * 🇺🇸 Coco Gauff / 🇺🇸 Jessica Pegula def. 🇨🇦 Gabriela Dabrowski / 🇲🇽 Giuliana Olmos, 1–6, 7–5, [10–4]

Seeds

 * 1 Rankings are as of September 12, 2022.

Other entrants
The following players received wildcards into the main draw:
 * 🇺🇸 Brandon Holt
 * 🇺🇸 Zachary Svajda
 * 🇪🇸 Fernando Verdasco

The following players received entry from the qualifying draw:
 * 🇺🇸 Christopher Eubanks
 * 🇺🇸 Mitchell Krueger
 * 🇦🇷 Facundo Mena
 * 🇺🇸 Emilio Nava

Withdrawals

 * Before the tournament
 * 🇩🇪 Daniel Altmaier → replaced by 🇦🇺 Jason Kubler
 * Cristian Garín → replaced by 🇺🇸 Steve Johnson
 * 🇰🇷 Kwon Soon-woo → replaced by 🇺🇸 Stefan Kozlov
 * 🇨🇿 Jiří Veselý → replaced by 🇦🇺 Christopher O'Connell

Seeds

 * 1 Rankings are as of September 12, 2022.

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇺🇸 Bradley Klahn / 🇪🇸 Fernando Verdasco
 * 🇺🇸 Keegan Smith / Sem Verbeek

The following pair received entry as alternates:
 * 🇫🇷 Jonathan Eysseric / 🇳🇿 Artem Sitak

Withdrawals

 * 🇺🇸 William Blumberg / Alejandro Tabilo → replaced by 🇺🇸 Evan King / 🇺🇸 Denis Kudla
 * 🇺🇸 Robert Galloway / 🇺🇸 Alex Lawson → replaced by 🇫🇷 Jonathan Eysseric / 🇳🇿 Artem Sitak
 * Cristian Garín / 🇲🇽 Hans Hach Verdugo → replaced by 🇲🇽 Hans Hach Verdugo / Treat Huey
 * 🇦🇺 Max Purcell / 🇦🇺 Luke Saville → replaced by 🇦🇺 Jason Kubler / 🇦🇺 Luke Saville

Seeds

 * 1 Rankings are as of October 3, 2022.

Other entrants
The following players received wildcards into the main draw:
 * 🇨🇦 Leylah Fernandez
 * Maria Sakkari
 * 🇺🇸 Sloane Stephens
 * 🇺🇸 CoCo Vandeweghe

The following players used a protected ranking to enter the main draw:
 * 🇨🇦 Bianca Andreescu
 * 🇺🇸 Sofia Kenin

The following players received entry from the qualifying draw:
 * 🇺🇸 Louisa Chirico
 * 🇺🇸 Caroline Dolehide
 * 🇺🇸 Robin Montgomery
 * 🇨🇴 Camila Osorio
 * 🇦🇺 Ellen Perez
 * Donna Vekić

The following players received entry as lucky losers:
 * Jil Teichmann
 * 🇨🇳 Zheng Qinwen

Withdrawals

 * 🇧🇷 Beatriz Haddad Maia → replaced by Liudmila Samsonova
 * 🇪🇪 Anett Kontaveit → replaced by 🇨🇦 Bianca Andreescu
 * Veronika Kudermetova → replaced by Jil Teichmann
 * 🇨🇿 Petra Kvitová → replaced by 🇮🇹 Martina Trevisan
 * Jeļena Ostapenko → replaced by 🇺🇸 Alison Riske-Amritraj
 * 🇰🇿 Elena Rybakina → replaced by 🇨🇳 Zheng Qinwen

Seeds

 * 1 Rankings are as of October 3, 2022.

Other entrants
The following pair received a wildcard into the doubles main draw:
 * 🇺🇸 Alyssa Ahn / 🇺🇸 Katherine Hui

Withdrawals

 * 🇰🇿 Anna Danilina / 🇧🇷 Beatriz Haddad Maia → replaced by 🇰🇿 Anna Danilina / Aliaksandra Sasnovich