2022 San Diego Open – Men's singles

Brandon Nakashima defeated Marcos Giron in the final, 6–4, 6–4 to win the singles tennis title at the 2022 San Diego Open. It was his first ATP Tour title, and he won it in his hometown of San Diego.

Casper Ruud was the reigning champion, but competed at the Laver Cup instead.

Seeds
The top four seeds received a bye into the second round. • #🇬🇧 Dan Evans (semi-finals)

• #🇺🇸 Jenson Brooksby (quarter-finals)

• #🇺🇸 Marcos Giron (final)

• #🇪🇸 Pedro Martínez (second round)

• #🇺🇸 Brandon Nakashima (champion)

• # Alejandro Tabilo (second round)

• #🇦🇺 James Duckworth (quarter-finals)

• #🇺🇸 J. J. Wolf (second round)

Seeds
• # 🇦🇷 Juan Pablo Ficovich (first round)

• # 🇦🇷 Facundo Mena (qualified)

• # 🇺🇸 Christopher Eubanks (qualified)

• # 🇺🇸 Emilio Nava (qualified)

• # 🇺🇸 Mitchell Krueger (qualified)

• # 🇺🇸 Ernesto Escobedo (qualifying competition)

• # 🇺🇸 Aleksandar Kovacevic (qualifying competition)

• # 🇩🇪 Sebastian Fanselow (first round)

Qualifiers
• # 🇺🇸 Mitchell Krueger

• # 🇦🇷 Facundo Mena

• # 🇺🇸 Christopher Eubanks

• # 🇺🇸 Emilio Nava