2022 San Diego Open – Women's singles

Iga Świątek defeated Donna Vekić in the final, 6–3, 3–6, 6–0 to win the women's singles tennis title at the 2022 San Diego Open. It was her eighth title of the 2022 season. By winning the title, Świątek became the first player since Serena Williams in 2013 to win more than 10,000 ranking points in a single season.

This was the first WTA Tour-level event to be held in the San Diego area since 2013.

Seeds
The top four seeds received a bye into the second round. • #🇵🇱 Iga Świątek (champion)

• #🇪🇸 Paula Badosa (quarterfinals)

• # Aryna Sabalenka (quarterfinals)

• #🇺🇸 Jessica Pegula (semifinals)

• # Maria Sakkari (first round)

• #🇺🇸 Coco Gauff (quarterfinals)

• #🇫🇷 Caroline Garcia (first round)

• # Daria Kasatkina (second round)

Seeds
• # Liudmila Samsonova (moved to main draw)

• # 🇨🇳 Zhang Shuai (first round)

• # 🇨🇳 Zheng Qinwen (qualifying competition, lucky loser)

• # Aliaksandra Sasnovich (first round)

• # 🇪🇪 Kaia Kanepi (first round)

• # Jil Teichmann (qualifying competition, lucky loser)

• # 🇺🇸 Bernarda Pera (qualifying competition)

• # 🇰🇿 Yulia Putintseva (first round)

• # 🇺🇸 Madison Brengle (first round)

• # Anna Kalinskaya (qualifying competition, retired)

• # 🇨🇴 Camila Osorio (qualified)

• # Donna Vekić (qualified)

Qualifiers
• # 🇦🇺 Ellen Perez

• # 🇺🇸 Robin Montgomery

• # 🇨🇴 Camila Osorio

• # 🇺🇸 Louisa Chirico

• # Donna Vekić

• # 🇺🇸 Caroline Dolehide

Lucky losers
• # Jil Teichmann

• # 🇨🇳 Zheng Qinwen