2022 San Juan Knights season

The 2022 San Juan Knights season was the third season of the franchise in the Maharlika Pilipinas Basketball League (MPBL).

Coming off of back-to-back National Finals appearances, San Juan's start to the season came out slow with only one win out of their first four games. The Knights would continue to push on by winning 13 of the remaining 17 games to finish the season 14–7 in a three-way tie for the second seed in the North. By tiebreaker criteria, San Juan would claim the third seed.

After sweeps against Valenzuela and Pasig City, San Juan would reach their third consecutive Division Finals appearance. They were matched against the Nueva Ecija Rice Vanguards, who have remained undefeated in 25 games up to that point. On opposing grounds, the Knights would lead the Rice Vanguards to their first loss of the entire season in game 1 of the North Division Finals series. Despite that, San Juan would fall to Nueva Ecija in the next two games, missing the National Finals for the first time in the team's MPBL history and igniting the rivalry between the two teams.

Preseason
San Juan was one of 22 teams that took part in the 2021 MPBL Invitational. The team ended their run in the Quarterfinals after losing to the Pasig Sta. Lucia Realtors in the Quarterfinals.