2022 San Marino Open – Singles

Holger Rune was the defending champion but chose not to defend his title.

Pavel Kotov won the title after defeating Matteo Arnaldi 7–6(7–5), 6–4 in the final.

Seeds
• # 🇪🇸 Carlos Taberner (second round)

• # Pavel Kotov (champion)

• # 🇮🇹 Giulio Zeppieri (first round)

• # 🇮🇹 Flavio Cobolli (first round)

• # 🇮🇹 Marco Cecchinato (semifinals)

• # 🇫🇷 Alexandre Müller (first round)

• # Nino Serdarušić (first round)

• # 🇮🇹 Matteo Arnaldi (final)