2022 Sanremo Challenger – Singles

This was the first edition of the tournament since it was discontinued in 2011.

Holger Rune won the title after defeating Francesco Passaro 6–1, 2–6, 6–4 in the final.

Seeds
• # Holger Rune (champion)

• # 🇮🇹 Gianluca Mager (semifinals)

• # 🇲🇩 Radu Albot (second round)

• # 🇫🇷 Pierre-Hugues Herbert (first round)

• # 🇫🇷 Hugo Grenier (first round)

• # 🇮🇹 Flavio Cobolli (first round)

• # 🇮🇹 Thomas Fabbiano (quarterfinals)

• # 🇫🇷 Alexandre Müller (second round)