2022 Santa Cruz Challenger – Singles

This was the first edition of the tournament as part of the Legión Sudamericana.

Francisco Cerúndolo won the title after defeating Camilo Ugo Carabelli 6–4, 6–3 in the final.

Seeds
• # 🇧🇴 Hugo Dellien (semifinals)

• # 🇸🇰 Andrej Martin (first round)

• # 🇦🇷 Francisco Cerúndolo (champion)

• # 🇦🇷 Tomás Martín Etcheverry (first round, retired)

• # 🇨🇿 Zdeněk Kolář (second round)

• # 🇪🇸 Fernando Verdasco (quarterfinals)

• # 🇦🇷 Facundo Mena (second round)

• # 🇦🇷 Camilo Ugo Carabelli (final)