2022 Santa Cruz Challenger II – Doubles

Diego Hidalgo and Cristian Rodríguez were the defending champions but lost in the semifinals to Jesper de Jong and Bart Stevens.

De Jong and Stevens won the title after defeating Nicolás Barrientos and Miguel Ángel Reyes-Varela 6–4, 3–6, [10–6] in the final.

Seeds
• # 🇦🇷 Guillermo Durán / 🇧🇷 Fernando Romboli (quarterfinals)

• # 🇻🇪 Luis David Martínez / 🇧🇷 Felipe Meligeni Alves (quarterfinals)

• # 🇨🇴 Nicolás Barrientos / 🇲🇽 Miguel Ángel Reyes-Varela (final)

• # 🇵🇪 Sergio Galdós / Gonçalo Oliveira (quarterfinals)