2022 Santa Cruz Futebol Clube season

The 2022 season was Santa Cruz's 109th season in the club's history. Santa Cruz competed in the Campeonato Pernambucano, Série D and Copa do Nordeste.

Overall
{| class="wikitable"
 * Games played || 30 (1 Copa do Nordeste, 11 Pernambucano, 18 Série D)
 * Games won || 12 (0 Copa do Nordeste, 6 Pernambucano, 6 Série D)
 * Games drawn || 10 (1 Copa do Nordeste, 3 Pernambucano, 6 Série D)
 * Games lost || 8 (0 Copa do Nordeste, 2 Pernambucano, 6 Série D)
 * Goals scored || 41
 * Goals conceded || 34
 * Goal difference || +7
 * Best results (goal difference) || 4–1 (A) v Atlético de Alagoinhas – Série D – 2022.06.27
 * Worst result (goal difference)|| 0–4 (H) v Retrô – Pernambucano – 2022.02.26
 * Top scorer || Hugo Cabral and Rafael Furtado (7)
 * Goals conceded || 34
 * Goal difference || +7
 * Best results (goal difference) || 4–1 (A) v Atlético de Alagoinhas – Série D – 2022.06.27
 * Worst result (goal difference)|| 0–4 (H) v Retrô – Pernambucano – 2022.02.26
 * Top scorer || Hugo Cabral and Rafael Furtado (7)
 * Best results (goal difference) || 4–1 (A) v Atlético de Alagoinhas – Série D – 2022.06.27
 * Worst result (goal difference)|| 0–4 (H) v Retrô – Pernambucano – 2022.02.26
 * Top scorer || Hugo Cabral and Rafael Furtado (7)
 * Top scorer || Hugo Cabral and Rafael Furtado (7)
 * Top scorer || Hugo Cabral and Rafael Furtado (7)