2022 Savannah Challenger – Singles

Federico Coria was the defending champion but chose not to defend his title.

Jack Sock won the title after defeating Christian Harrison 6–4, 6–1 in the final.

Seeds
• # 🇦🇷 Tomás Martín Etcheverry (quarterfinals)

• # 🇺🇸 Stefan Kozlov (first round)

• # 🇪🇨 Emilio Gómez (first round, retired)

• # 🇺🇸 Jack Sock (champion)

• # Tomás Barrios Vera (first round)

• # 🇺🇸 J. J. Wolf (semifinals)

• # 🇺🇸 Tennys Sandgren (first round)

• # 🇺🇸 Bjorn Fratangelo (semifinals)