2022 Serbia Open – Singles

Andrey Rublev defeated Novak Djokovic in the final, 6–2, 6–7(4–7), 6–0 to win the singles tennis title at the 2022 Serbia Open.

Matteo Berrettini was the reigning champion, but chose not to defend his title.

Seeds
The top four seeds received a bye into the second round. • # 🇷🇸 Novak Djokovic (final)

• # Andrey Rublev (champion)

• # Karen Khachanov (semifinals)

• # Aslan Karatsev (second round)

• # Cristian Garín (first round)

• # 🇮🇹 Fabio Fognini (semifinals)

• # 🇷🇸 Miomir Kecmanović (quarterfinals)

• # 🇷🇸 Filip Krajinović (second round)

Seeds
• # 🇨🇿 Jiří Lehečka (qualified)

• # 🇯🇵 Taro Daniel (qualified)

• # 🇸🇰 Norbert Gombos (qualifying competition)

• # 🇧🇷 Thiago Monteiro (qualified)

• # 🇬🇧 Liam Broady (qualifying competition)

• # 🇧🇦 Damir Džumhur (qualifying competition)

• # 🇮🇹 Flavio Cobolli (qualifying competition)

• # Roman Safiullin (qualified)

Qualifiers
• # 🇨🇿 Jiří Lehečka

• # 🇯🇵 Taro Daniel

• # Roman Safiullin

• # 🇧🇷 Thiago Monteiro