2022 Sibiu Open – Singles

Stefano Travaglia was the defending champion but chose not to defend his title.

Nerman Fatić won the title after defeating Damir Džumhur 6–3, 6–4 in the final.

Seeds
• # 🇦🇷 Federico Coria (semifinals)

• # 🇦🇹 Filip Misolic (quarterfinals)

• # 🇨🇿 Zdeněk Kolář (second round)

• # 🇦🇷 Thiago Agustín Tirante (first round)

• # 🇮🇹 Riccardo Bonadio (first round)

• # 🇧🇦 Damir Džumhur (final)

• # 🇧🇪 Kimmer Coppejans (first round)

• # 🇷🇸 Nikola Milojević (second round)