2022 Southeast Missouri State Redhawks football team

The 2022 Southeast Missouri State Redhawks football team represented Southeast Missouri State University (SEMO) as a member of the Ohio Valley Conference (OVC) during the 2022 NCAA Division I FCS football season. Led by ninth-year head coach Tom Matukewicz, the Redhawks played their home games at Houck Stadium in Cape Girardeau, Missouri.

Although Southeast Missouri State finished as OVC co-champions with UT Martin (both with 5–0 OVC records), SEMO was awarded the automatic bid to the 2022 FCS playoffs while UT Martin was not. Both teams had identical records in conference play, and no game had been played between the two teams that season, as a result of schedule changes to accommodate new member Lindenwood. The tiebreaker to determine an automatic conference bid ultimately then came down to a coin flip, which the Redhawks won.