2022 St. Petersburg Ladies' Trophy – Singles

Anett Kontaveit defeated Maria Sakkari in the final, 5–7, 7–6(7–4), 7–5 to win the singles title at the 2022 St. Petersburg Ladies' Trophy. Kontaveit's victory in the final was her 20th consecutive match win on indoor hard courts, dating back to the 2021 Ostrava Open; this is the longest such streak since Justine Henin won 22 matches on indoor courts between October 2007 and May 2010.

Daria Kasatkina was the defending champion, but withdrew before the tournament began.

Seeds
• # Maria Sakkari (final)

• # 🇪🇪 Anett Kontaveit (champion)

• # 🇰🇿 Elena Rybakina (second round, withdrew)

• # 🇷🇺 Anastasia Pavlyuchenkova (withdrew due to a left knee injury)

• # Belinda Bencic (quarterfinals)

• # 🇨🇿 Petra Kvitová (second round)

• # Jeļena Ostapenko (semifinals)

• # 🇧🇪 Elise Mertens (quarterfinals)

Seeds
• # 🇸🇪 Rebecca Peterson (qualified)

• # 🇸🇰 Kristína Kučová (first round)

• # 🇷🇺 Varvara Gracheva (qualified)

• # 🇭🇺 Anna Bondár (first round)

• # 🇫🇷 Kristina Mladenovic (first round)

• # 🇺🇸 Bernarda Pera (qualifying competition, lucky loser)

• # 🇷🇴 Ana Bogdan (qualifying competition)

• # Kaja Juvan (qualified)

Qualifiers
• # 🇸🇪 Rebecca Peterson

• # Kaja Juvan

• # 🇷🇺 Varvara Gracheva

• # 🇩🇪 Jule Niemeier

Lucky loser
• # 🇺🇸 Bernarda Pera